| Customization: | Available |
|---|---|
| CAS No.: | 1051375-19-9 |
| Formula: | C20h18f2n3nao5 |
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| Product Name | Dolutegravir Sodium |
| CAS | 1051375-19-9 |
| MF | C20H20F2N3NaO5 |
| MW |
443.38 |
| EINECS |
812-620-6 |
Dolutegravir sodium (Tivicay), developed and marketed by GlaxoSmithKline, was approved by the FDA in August 2013 as a novel integrase inhibitor for the treatment of HIV infection. Dolutegravir was fast-tracked by the FDA in February 2012, and joins an important class of drugs known as Integrase Strand Transfer inhibitors (INSTi's). INSTi's are characterized by their two-metal-chelating scaffolds, which are known to chelate Mg2+ cofactors in the enzyme active site, l interrupting function of HIV-1 integrase, which is essential for replication of viral DNA into host chromatin.Other drugs in this class, raltegravir and elvitegravir, are known to require either high dosages or PK boosting agents, respectively, with raltegravir also exhibiting substantial loss of potency in several major HIV-1 integrase mutation pathways. Dolutegravir was pursued with the goal of developing a novel INSTi with a once-daily, low-dosage treatment with improved resistance profile and without the need for the use of a PK boosting agent. Dolutegravir sodium has been approved for treating a broad population of HIV-infected patients, including adults undergoing their first treatment as well as those who have been treated with other integrase transfer strand inhibiting agents.
Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales.
Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world.
1.Can I get some samples?
Yes, usually a 10-20g sample.
2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.
3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.
4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.
5. What is the shelf life for the products?
Most products shelf life 24-36 months.
6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.
7. How about the validity of the offer?
Usually, our offer is valid for 1 week. However, validity might vary between different products.
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