Hot Sale Professional Pharmaceutical Intermediate Memantine CAS 19982-08-2 with Best Price

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Grade: Pharmaceutcial Grade
• CAS: 19982-08-2
• Storage: Cool Dry Place
• Deliver Time: 5-10 Days
• Appearance: White Powder
• Test Method: HPLC UV
• Sample: Available
• Shipping Method: Air(UPS, FedEx, TNT, EMS) or Sea
• Mf: C12h22cln
• COA: Available
• MOQ: 50 Grams
• Shelf Life: 2 Years
• Transport Package: Bag or Drum
• Specification: 1kg/bag 25kg/drum
• Origin: China
• Production Capacity: 10000kg/Months

Product Description

Product Description

Basic Information
 

Product name	Memantine
Cas number	19982-08-2
Molecular formula	C12H22ClN
Molecular weight	215.76
Appearance	white powde
Melting point	153
Boiling point	239.8 at 760 mmHg
Relative density	1.046

What is Memantine?

Memantine hydrochloride is a raw material. It should be prescribed by experienced doctors in the diagnosis and treatment of Alzheimer's dementia and guided by patients. Treatment can only begin when there are caregivers around the patient who regularly supervise the patient's medication. Dementia should be diagnosed in accordance with current diagnostic criteria and guidelines.

Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Treatment should only be continued if beneficial effects are seen. It is taken by mouth.
Memantine was approved for medical use in the United States in 2003. It is available as a generic medication. In 2017, it was the 149th most commonly prescribed medication in the United States, with more than four million prescriptions

 

Detailed Photos

 

Function and Application

Memantine Benefits
Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer's disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European.
The development of Alzheimer's disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity.
Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs).
Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington's disease, ALS and movement disorders, among other. 

Medical Use   
Memantine is used to treat moderate-to-severe Alzheimer's disease, especially for people who are intolerant of or have a contraindication to AChE (acetylcholinesterase) inhibitors.One guideline recommends memantine or an AChE inhibitor be considered in people in the early-to-mid stage of dementia.

Memantine has been associated with a modest improvement; with small positive effects on cognition, mood, behavior, and the ability to perform daily activities in moderate-to-severe Alzheimer's disease. There does not appear to be any benefit in mild disease.

Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements" in a 2017 review. The UK National Institute of Clinical Excellence (NICE) issued guidance in 2018 recommending consideration of the combination of memantine with donepezil in those with moderate-to-severe dementia. Effects in autism are unclear. Recent scientific journal reports are showing guarded promise with severe obsessive compulsive disorder.

COA

Item	Requirements	Test Results
appearance	White or almost white crystalline powder	White crystalline powder
Identification	IR	Comply
Related substance	1-methyladamantane ≤0.3% 1,3,5 -trimethyladamantane ≤0.3% Unknow impuritiy     ≤0.1% Total impurity ≤0.5%	0.13% 0.14% <0.1% <0.4%
Residue on ignition	≤0.1%	0.06%
Heavy matal	≤10ppm	<10ppm
Loss on drying	≤0.5%	0.29%
Assay	98.5-101.0%	99.13%
Residual Solvents	Ethyl Acetat: ≤0.5% Ethanol: ≤0.5%	0.08% 0.12%
PH	4.5-5.5	5.3
Microbial Limits	Max 5*102 aerobes and fungl per 1g  E. Coli: Negative Salmonella: Negative	Pass
Size of distributed particles	Pass 100μ m	Conforms
Conclusion	Meet the requirements

 

Packaging & Shipping

Company Profile

Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales. 

Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world. 

FAQ

1.Can I get some samples?
Yes, usually a 10-20g sample.

2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.

3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.

4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.

5. What is the shelf life for the products?
Most products shelf life 24-36 months. 

6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.

7. How about the validity of the offer? 
Usually, our offer is valid for 1 week. However, validity might vary between different products.