| Customization: | Available |
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| Classification: | High Purity Material |
| Grade: | Pharmaceutcial Grade, AR |
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| Product Name | Abemaciclib |
| CAS | 1231929-97-7 |
| Appearance | White crystalline powder |
| MF | C27H32F2N8 |
| MW | 506.606 |
| Purity | 99% |
| Shelf Life | 2 Years |
Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers.
Function
Abemaciclib is a CD4/6 kinase inhibitor. This type of kinase is activated by connecting D-cyclin. In breast cancer cell lines that are estrogen receptor positive (HR+), cyclin D1 and CD4/ 6 It can bind to phosphorylation of retinoblastoma protein (Rb), cell cycle progression and cell proliferation. In vitro, continuous exposure to Abemaciclib inhibits Rb phosphorylation and prevents entry from G1 into the S phase of the cell cycle, leading to cell senescence and apoptosis. In breast cancer xenotransplantation models, Abemaciclib monotherapy or combined with anti-estrogens can be administered continuously every day to shrink tumors.
Application
Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers.
Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales.
Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world.
1.Can I get some samples?
Yes, usually a 10-20g sample.
2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.
3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.
4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.
5. What is the shelf life for the products?
Most products shelf life 24-36 months.
6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.
7. How about the validity of the offer?
Usually, our offer is valid for 1 week. However, validity might vary between different products.
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