| Customization: | Available |
|---|---|
| Classification: | High Purity Material |
| Grade: | Pharmaceutcial Grade, AR |
|
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| Product name: Rosuvastatin Calcium |
| Other name: Crestor |
| Appearance: White Crystals Powder |
| CAS NO.:147098-20-2 |
| M.F.: C22H27Ca0.5FN3O6S |
| M.W.: 500.57 |
| Grade: Pharmaceutical grade |
Rosuvastatin, one of the two new statins launched for the treatment of hypercholesterolemia, has high hepato-selectivity and more potent inhibitory effect on HMG-CoA reductase than the previously marketed statins. In rat hepatocytes, it inhibits cholesterol biosynthesis with an IC50 of 1.12 nM, which is ~100-fold higher potency than pravastatin. Rosuvastatin is synthesized in a 12-step sequence, entailing the construction of a pyrimidinyl aldehyde intermediate in eight steps and subsequent introduction of the dihydroxyheptenoate side chain via Wittig reaction with a bketophosphorane reagent and stereoselective carbonyl reduction of the resultant enone.
Specification
|
Tests |
Specifications |
Results |
|
Appearance |
A White to off-white powder |
Complies |
|
Specific Rotation |
+17°~+21° |
+20° |
|
Identification |
A. Meets the requirement B. UV: λmax=243nm C. IR: similar to Reference Substance D.X-ray: similar to Reference Substance |
Complies Complies Complies Complies |
|
Chloride |
≤0.1% |
Complies |
|
Sulphate |
≤0.1% |
Complies |
|
Enantiomer |
≤0.15% |
Undetected |
|
Calcium |
3.9%~4.3% |
4.1% |
|
Related substances |
Diastereomer≤0.15% |
0.06% |
|
5-oxo-Rosucastatin≤0.15% |
Undetected |
|
|
Photo degradation 1≤0.15% |
Undetected |
|
|
Photo degradation 2≤0.15% |
Undetected |
|
|
Rosuvastatin lactone≤0.15% |
Undetected |
|
|
Rosuvastatin methyl ester≤0.15% |
Undetected |
|
|
Rosuvastatin isoamyl ester≤0.15% |
Undetected |
|
|
Any unknown impurity≤0.10% |
0.05% |
|
|
Total impurities≤0.75% |
0.28% |
|
|
Water |
≤3.0% |
2.1% |
|
Isoamyl Bromide |
≤37.5ppm |
≤37.5ppm |
|
Residual solvents |
Ethyl ether≤300ppm Undetected |
Complies |
|
Acetonitrile≤410ppm Undetected |
Undetected |
|
|
Isoamyl alcohol≤5000ppm Undetected |
Undetected |
|
|
DMF≤880ppm Undetected |
Undetected |
|
|
Assay |
98.5%~102.0%( caculated on the anhydrous basis) |
99.8% |
Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales.
Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world.
1.Can I get some samples?
Yes, usually a 10-20g sample.
2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.
3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.
4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.
5. What is the shelf life for the products?
Most products shelf life 24-36 months.
6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.
7. How about the validity of the offer?
Usually, our offer is valid for 1 week. However, validity might vary between different products.
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