| Customization: | Available |
|---|---|
| CAS No.: | 1360540-81-3 |
| Formula: | C18h16o4 |
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| Product Name | Pharmaceutical Chemical cas 1360540-81-3 bulk SM04554 powder price |
| Appearance | White powder |
| Molecular formula | C18H16O4 |
| Molecular Weight | 296.32 |
| Keywords | SM04554 price,bulk SM04554,Pharmaceutical Chemical SM04554 |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
SM04554 is a molecule that acts at the level of the skin androgen receptor, blocking dihydrotestosterone (DHT) from binding to the receptor in the cell. The molecule has a unique mechanism that acts at the skin surface, and is quickly metabolized to free inactive cortexolone, a substance naturally found in the body. The molecule has been evaluated in a variety of animal models as well as initial human trials in Europe for acne and androgenic alopecia. The results of these studies demonstrate that sm04554 appears to have potent anti-androgenic activity without significant local or systemic side effects.
Function
SM04554 reduces eosinophilic airway inflammation and is well tolerated in patients with persistent moderate-to-severe asthma and raised sputum eosinophil counts despite inhaled corticosteroid treatment. SM04554 demonstrates a favorable safety profile.
Application
SM04554 is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment.
SM04554 displayed high affinity for the human CRTh2 receptor (1.14 ± 0.44 nM) expressed in Chinese hamster ovary cells, the binding being reversible and competitive with the native agonist prostaglandin D2(PGD2). SM 04554 was also a potent inhibitor of PGD2-induced cytokine release in human Th2 cells.
Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales.
Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world.
1.Can I get some samples?
Yes, usually a 10-20g sample.
2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.
3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.
4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.
5. What is the shelf life for the products?
Most products shelf life 24-36 months.
6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.
7. How about the validity of the offer?
Usually, our offer is valid for 1 week. However, validity might vary between different products.
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