| Customization: | Available |
|---|---|
| Classification: | High Purity Material |
| Grade: | AR |
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| Name | Linaelotide Acetate |
| CAS No. | 851199-59-2 |
| Purity | >99% |
| Molecular Formula | C59H79N15O21S6 |
| Molecular weight | 1526.74 |
| Appearance | White power |
Linaclotide is an administered, peptide agonist of guanylate cyclase 2C for the treatment of irritable bowel syndrome. Chemically, it is a heterodetic cyclic peptide and consists of fourteen amino acids.
| Contents of testing | Specifications | ||
| Appearance | White or almost white crystalline powder | ||
| Identity by HPLC | The reaction is same with the reference substance | ||
| Amino Acid Composition | ±20% of theoretical | ||
| Purity (HPLC) | ≥ 98.0% | ||
| Related Substance(By HPLC) | Total Impurities(%)≤ 2.0% Largest Single Impurity(%)≤ 1.0% |
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| Acetate Content(By HPLC) | ≤15% | ||
| Water Content(By HPLC) | ≤5.0% | ||
| Bacterial Endotoxins | ≤5IU/mg | ||
Function
Linaclotide is a peptide agonist of the guanylate cyclase 2C.
This compound reduces the activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements.
It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome (IBS-C) in adults.
Application
Linaclotide is an administered, peptide agonist of guanylate cyclase 2C for the treatment of irritable bowel syndrome. Chemically, it is a heterodetic cyclic peptide and consists of fourteen amino acids.
Linaclotide is used to treat certain types of bowel problems (irritable bowel syndrome with constipation, chronic idiopathic constipation). It works by increasing fluid in your intestines and helping speed up movement of food through the gut. Linaclotide may improve stool texture and lessen symptoms such as bloating, abdominal pain/discomfort, straining, and feelings of incomplete bowel movements.
Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales.
Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world.
1.Can I get some samples?
Yes, usually a 10-20g sample.
2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.
3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.
4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.
5. What is the shelf life for the products?
Most products shelf life 24-36 months.
6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.
7. How about the validity of the offer?
Usually, our offer is valid for 1 week. However, validity might vary between different products.
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