High Purity 99% Darunavir CAS 206361-99-1 Darunavir Powder

• CAS No.: 206361-99-1
• Formula: C27h37n3o7s
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Technical
• Colour: White
• Grade: Pharmaceutcial Grade
• CAS: 206361-99-1
• Storage: Cool Dry Place
• Deliver Time: 5-10 Days
• Test Method: HPLC UV
• Sample: Available
• Shipping Method: Air(UPS, FedEx, TNT, EMS) or Sea
• MW: 547.664
• Mf: C27h37n3o7s
• COA: Available
• MOQ: 50 Grams
• Transport Package: Bag or Drum
• Specification: 1kg/bag 25kg/drum
• Origin: China
• Production Capacity: 10000kg/Months

Product Description

Product Description

Product name	High Purity 99% Darunavir CAS 206361-99-1
Appearance	white powder
Assay	99%
CAS	206361-99-1
Shelf Life	24 months when properly stored
Storage	Cool Dry Place

What is Darunavir?
 

Darunavir is the latest weapon in the arsenal of agents to combat human immunodeficiency virus type 1(HIV-1).
As an HIV-1 protease inhibitor, its mechanism of action involves blocking the cleavage of the gag and gag-pol polyproteins into functional proteins essential for the production of infectious progeny virus;

the result is the production of immature, noninfectious viral particles.

Compared to predecessor HIV protease inhibitors, darunavir retains activity against resistant stains, a critical factor with the continual emergence of multidrug- resistant (MDR) mutants. Despite experiencing a 13-fold reduction in binding to MDR HIV-1 protease, this binding is 1.5 orders of magnitude tighter than the first-generation protease inhibitors.

Detailed Photos

 

Function and Application

Function of Darunavir

Darunavir exhibits less than a 10-fold decrease in susceptibility in cell culture against 90% of 3309 clinical isolatesresistant to amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, and tipranavir.In contrast, darunavir-resistant viruses display limited susceptibility to only tipranavir, suggesting limited cross-resistance between these two protease inhibitors.To avoid the issues of the peptide-based protease inhibitors, darunavir has evolved from a structure-based design effort to minimize peptidic features and reduce molecular weight and complexity.

Application of darunavir

Treatment of HIV infection (in combination with other antiretroviral drugs)Darunavir is less affected than other protease inhibitors by mutations to resistance, but subgroups with more than 10 cumulative mutations show a >10-fold (median value) decrease in susceptibility. The major resistance mutations occur at positions 50 (150V), 54 (I50M/L), 76 (L76V) and 84 (I84V) of the protease gene.

Packaging & Shipping

Company Profile

Shandong Longilat Biotechnology Co., Ltd was established in 2015. It is a high-tech professional and technological enterprise integrating R & D, production, and sales. 

Longilat 's main products are food additives, plant extracts, cosmetic raw materials, feed additives, animal extract, amino acids and vitamins. Most of our products are derived from natural plants. Marketing services are available in many countries around the world. 

FAQ

1.Can I get some samples?
Yes, usually a 10-20g sample.

2.What's your MOQ?
Our MOQ is flexible, usually 1kg-10kg for a trial order is acceptable.

3. Is there a discount?
Of course, welcome to contact us. Price would be different based on different quantities. For bulk quantity, we will have a discount for you.

4. How to deliver the goods?
≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.

5. What is the shelf life for the products?
Most products shelf life 24-36 months. 

6. What's your delivery time?
Usually, shipment will be made within 7-15 days against confirmed order.

7. How about the validity of the offer? 
Usually, our offer is valid for 1 week. However, validity might vary between different products.